Because the expression patterns of SHC1, GAPDH, JUN, PXN, NFKBIA, HNRNPK, SNCA, TDG, TNFRSF1A, FN1 and ITGB5 were also correlated with AD progression, these genes may be potential diagnostic biomarkers in monitoring AD progression. Here, ITGB5 is linked to Alzheimer disease.