Because the expression patterns of SHC1, GAPDH, JUN, PXN, NFKBIA, HNRNPK, SNCA, TDG, TNFRSF1A, FN1 and ITGB5 were also correlated with AD progression, these genes may be potential diagnostic biomarkers in monitoring AD progression. The gene discussed is SNCA; the disease is Alzheimer disease.