Compared with a study on the transcriptome of blood mononuclear cells by Olivier et al. (60 samples) [64], we found that hub genes STAT3, GNB2L1, SHC1, UBE2I, GAPDH, JUN, AKT1, PXN, BAG3 and DVL2 were differentially expressed in the blood of AD patients. Here, SHC1 is linked to Alzheimer disease.