Compared with a study on the transcriptome of blood mononuclear cells by Olivier et al. (60 samples) [64], we found that hub genes STAT3, GNB2L1, SHC1, UBE2I, GAPDH, JUN, AKT1, PXN, BAG3 and DVL2 were differentially expressed in the blood of AD patients. The gene discussed is GAPDH; the disease is Alzheimer disease.