Interestingly, for most of the hub genes, the direction of the dys-regulation was consistent in aging and AD, including down-regulation of synaptic vesicle cycle, cytoskeleton, RNA transport and translation and NFT related hub genes, up-regulation of focal adhesion, TGFB signaling, HATs learning and memory, TNFR signaling and cell cycle re-entry, as well as dys-regulation of insulin and neurotrophin signaling. Here, INS is linked to Alzheimer disease.