The result demonstrate that TLR2 is an attractive target against metastasis, anti-TLR2 antibody could be used to combate the life-threatening metastasis.Thompson et al [11] showed that hepatoma cell lines express functional TLR2 receptors, which, when stimulated, initiate a signaling cascade that inhibits hepatitis B virus. Here, TLR2 is linked to hepatocellular carcinoma.