To date, at least 73 non-synonymous SNPs (nsSNPs) in the ERCC5 coding region have been identified (http://www.ncbi.nlm.nih.gov/SNP/), and 24 SNPs in the gene region have been studied for their association with cancer risk (Table S1), of which only four were nsSNPs (Figure S1). This evidence concerns the gene ERCC5 and cancer.