The mechanisms underlying the organ-specific nature of bone metastasis are governed by chemoattractants (e.g. CXCL12/SDF1), attachment molecules (e.g. ALCAM, annexin II), and cytokines regulating cell growth and angiogenesis (e.g. IL6 and VEGF) [6],[7]; however, the conditions and factors that regulate the expression or activity of these critical molecules to affect metastatic cancer cell bone colonization, establishment, tumor growth, metastatic progression, and recurrence remain unclear. Here, CXCL12 is linked to neoplasm.