Third, BMSC expression of Sdf1, a major cytokine promoting breast cancer cell migration, was unaffected by ISO treatment for 2, 6, or 24 h (Figure S3C); in breast cancer cells treated with ISO, the expression of RANK and CXCR4—the receptors for RANKL and SDF1, respectively—remained unchanged as well (Figure S3D,E). This evidence concerns the gene CXCL12 and breast carcinoma.