In this current study, we investigated the effect of 0.1% nepafenac, and 0.4% ketorolac on the BTX-B dry eye mouse model and did not find significant beneficial effects on objective parameters like tear production, corneal fluorescein staining and IL-1β and TNF-α expression in ocular surface epithelia although these parameters tended to improve. This evidence concerns the gene IL1B and Keratoconjunctivitis sicca.