The study demonstrated that the activity of the secretory form of phospholipase A2 group 2a (sPLA2-IIa),which is an important enzyme participating in inflammatory reactions including causing TNF-α and IL-1β pre-activation as well as increased PGE2 production, is significantly increased in the tears of dry eye patients [25,26]. Here, IL1B is linked to Keratoconjunctivitis sicca.