TMCO1 and open-angle glaucoma: In recent genome-wide association studies, susceptibility variants for POAG were identified at the caveolin 1 (CAV1) and caveolin 2 (CAV2) [12], transmembrane and coiled-coil domains 1 (TMCO1) and CDKN2B antisense RNA 1 (CDKN2B-AS1) [13] genes.