No enrichment for FOXD3 variants was observed in other ocular phenotypes: while the p.Arg273_Gly276dup mutation was detected in one case each of anophthalmia and congenital cataracts, no other significant variants in FOXD3 were identified in the sizable population screened with these phenotypes (n=123). Here, FOXD3 is linked to early-onset non-syndromic cataract.