TP53 and chronic myelogenous leukemia, BCR-ABL1 positive: NA is a non-competitive inhibitor of SIRTs at high concentrations and has been recently shown to be highly effective in killing CML cells through specific activation of the p53 pathway.16 Based on our observation that the sensitivity of NB-4, OCI-AML3 and MOLM-13 cells toward NA begins at 20 mM concentration (Fig. 5a), we used 20 mM of NA for our further experiments.