SIRT1 and chronic myelogenous leukemia, BCR-ABL1 positive: Indeed, it has been recently reported that in cases of CML inhibition of SIRT1 by NA results in p53 dependent decrease in cell proliferation.16 A thorough understanding of the pathway involved in the regulation of p53 activity will be extremely useful in the development of new strategies for treatment of cancer, including restoration of p53 function and selective killing of tumors with wild type or mutant p53.