TP53 and cancer: Our results are supported by the recent findings that inhibition of SIRT1 by NA induces cytotoxic effects on CML cells in p53 acetylation dependent manner.16 Intriguingly, the specificity of NA on SIRT1 is quite unclear due to its dual ability to either activate or inhibit SIRT1, depending on the dose and context.45, 47 Despite its use in the clinical trials as a therapy for cancers,48 further detailed investigation of its effects at molecular level is required.