We previously identified a common gene expression signature (Tag signature) comprised of approximately 120 named genes based upon the loss of p53 and Rb functions in several transgenic mouse models of epithelial cancers (including the C3(1)/Tag model of mammary cancer) where the functions of these two tumor suppressor genes are abrogated by the expression of the SV40 T-antigen (Tag) oncoprotein [8]. Here, RB1 is linked to neoplasm.