We sought to 1) determine whether expression levels of specific GR exon 1 mRNA transcript variants are altered in the lateral OFC in schizophrenia and bipolar disorder cases relative to controls, 2) quantify expression of GRα protein isoforms in the lateral OFC in schizophrenia and bipolar disorder compared to controls, and 3) determine if selected human GR gene (NR3C1) polymorphisms relate to GR mRNA or protein expression in the lateral OFC. The gene discussed is NR3C1; the disease is bipolar disorder.