Based on evidence of structural and functional abnormalities of the lateral OFC network in psychiatric illness, its functional relevance to psychiatric illness as an integrator of sensory information, and its possible sensitivity to stress, we hypothesised that GR mRNA and protein dysregulation would be evident in the lateral OFC, as in the DLPFC, in schizophrenia and bipolar disorder. The gene discussed is NR3C1; the disease is bipolar disorder.