In bipolar disorder cases, significant negative correlations were seen with age of onset for pan GR and GR-1B mRNA levels (r = −0.392, p < 0.05 and r = −0.387, p < 0.05 respectively), and with time in hospital for GR-1C mRNA levels (r = −0.363, p < 0.05). This evidence concerns the gene NR3C1 and bipolar disorder.