HTR1A and schizophrenia: At a molecular level, decreased glutamic acid decarboxylase 67 (GAD 67) expression has been reported in the lateral OFC in schizophrenia and bipolar disorder [31], while increased dopamine receptor (D3 and D4) mRNA, serotonin receptor 1A binding, N-methyl-D-aspartate receptor binding and metabotropic glutamate receptor protein expression have been identified throughout the OFC in schizophrenia [32-36].