Therefore, it is not surprising to confirm that SUMOylation is implicated in several human disorders such as neurodegenerative diseases associated to huntingtin, ataxin-1, tau, alpha-synuclein, DJ-1 or PARK-7 (Parkinson's disease 7), and superoxide dismutase 1 (SOD-1). The gene discussed is PARK7; the disease is neurodegenerative disease.