SAMHD1 and infection: The identification of SAMHD1 as a myeloid-specific restriction factor that could provide host-derived protection against infection provides an exciting foundation from which to launch further studies not only about the role of SAMHD1 in modulation of infection in macrophages, but about how controlled interference of imbalanced and scarce dNTPs in HIV-1 target cells could provide a protective measure against infection.