Recently it was found that repression of HAR1F by REST leads to its decreased expression in the striatum of Huntington’s disease (Johnson et al., 2010), and that REST also interacts with DGCR5 and TUG1 lncRNAs leading to DiGeorge syndrome and Huntington’s disease (Johnson et al., 2009; Johnson, 2011). The gene discussed is REST; the disease is juvenile Huntington disease.