KCNQ2 and bipolar disorder: In both bipolar disorder and schizophrenia sensorimotor gating is often impaired (Braff et al., 1995), and inhibition of KCNQ2 channels induced by GSK-3-dependent phosphorylation might be a potential mechanism underlying hyperexcitability and circuit dysfunction that accompany some of the clinical symptoms observed in these psychiatric disorders (Sharp and Hendren, 2007).