In order to investigate pathogenetic and epigenetic features associated with this intriguingly distinct behavior of anaplastic glioma compared to glioblastoma, it is of high interest analyzing large datasets of glioma for which DNA methylome data have been reported, and classifying them by their MGMT gene promoter methylation status for integration into multi-dimensional molecular and clinical data analysis. The gene discussed is MGMT; the disease is grade III glioma.