Anaplastic gliomas with CIMP accumulate other known favorable prognostic factors such as mutations of the isocitrate dehydroxygenase (IDH) genes, 1p/19 co-deletions, and also MGMT promoter methylation, in addition a plethora of other methylated genes whose contribution to response to therapy remains to be explored and exploited. This evidence concerns the gene MGMT and central nervous system cancer.