Other targets of interests include PTEN (phosphatase and tensin homolog), which functions as a tumor suppressor by negatively regulating intracellular levels of phosphatidylinositol-3,4,5-trisphosphate, substrates for AKT (tyrosine kinase B protein) in the intracellular AKT/PKB signaling pathway, and TENC1 (tensin-like C1 domain containing phosphatase), which is thought to act in a similar manner as PTEN in depriving substrates for AKT[84]. This evidence concerns the gene AKT1 and neoplasm.