Further analysis of the data demonstrated that those diagnosed with HNF1A-MODY under 25 years of age had significantly lower levels of PSP/reg1A than those diagnosed at the age of 25 years or over (median = 10.85 ng/ml, IQR = 9.41-12.12 ng/ml versus median = 15.40 ng/ml, IQR = 11.05-19.91 ng/ml, p = 0.0039, Figure 3). This evidence concerns the gene REG1A and supranuclear palsy, progressive, 1.