It is interesting to note that many of these changes also occur in patients with T2D - impaired insulin response to L-arginine [56], decreased islet glucose oxidation [57], increased whole body glucose uptake at basal glucose levels [58], decreased Gck, Hnf4α, and Pfk, and increased Pdx1 expression [19], [57]. The gene discussed is HNF4A; the disease is type 2 diabetes mellitus.