Our recent paper described diffuse immunoreactivity of AQP3 in a wide variety of human tissues such as squamous cell carcinoma of skin, esophagus and endometrial cervix, urothelial carcinoma, salivary carcinoma, etc. Medullary thyroid carcinomas have also been reported as positive for AQP3 [39]. This evidence concerns the gene AQP3 and squamous cell carcinoma.