Of note, TLR8 mRNA expression was significantly higher in the peritumoral tissue of SCC (13.93±0.57) as well as in the tumor center (7.46±4.99) compared to normal skin (p<0.05 for both) and significantly higher compared to BCC peritumoral (0.36±0.21) and BCC tumor center tissue (0.35±0.14) (p<0.01 for both) (Figure 3). This evidence concerns the gene TLR8 and skin basal cell carcinoma.