Filaggrin and keratin 10 expression in the tumor center was also higher compared to the tumor margin (0.44±0.22, p<0.001; 1.56±0.51, p<0.05) and to peritumoral tissue (0.62±0.18, p<0.001; 1.19±0.34, p<0.01). The gene discussed is KRT10; the disease is neoplasm.