Several of the genes in this profile have previously been shown to be involved in innate immune response, such as DDX58, CD45, CD36 and EVI2B. It is interesting to note that the different influenza strains used in this study triggered a highly strain specific host response, also involving genes transcribing key pattern recognition molecules for influenza like the DDX58/RIG-I. The gene discussed is RIGI; the disease is influenza.