Colorectal carcinoma and colorectal carcinoma metastases showed the strongest cytoplasmic Abi1 staining with no difference between microsatellite-stable (MSS) and -instable (MSI) tumors but with significant overexpression of Abi1 in KRAS-mutated carcinomas compared to healthy and inflamed mucosa, wild-type and BRAF-mutated HPP and SSP/A as well as wild-type tubular adenomas and wild-type invasive carcinomas. The gene discussed is ABI1; the disease is colorectal carcinoma.