In patients with chronic hepatitis the serpinB4-IgM(SCC103)/serpinB3-IgM median ratio was 1.40 (range 1.0–4.5), in patients with cirrhosis it was 1.10 (range 0.9–6.2), and in patients with HCC it was 1.08 (range 0.4–4.2). The gene discussed is SERPINB4; the disease is chronic hepatitis.