In patients with chronic hepatitis the serpinB4-IgM(SCC103)/serpinB3-IgM median ratio was 1.40 (range 1.0–4.5), in patients with cirrhosis it was 1.10 (range 0.9–6.2), and in patients with HCC it was 1.08 (range 0.4–4.2). This evidence concerns the gene SERPINB3 and hepatocellular carcinoma.