PARP1 and prostate neoplasm: In the differentiation model of prostate tumor progression used in this study, the changes in nuclear organization could be triggered by coordinated modifications in the expression of a few proteins (i.e. PARP, SATB1) and in the increased phosphorylation of lamin B. These modifications altering the NM structure could change the interactions between the NM and the MARs, consequently determining variations in the loop dimensions and therefore in gene expression, which may ultimately give rise to a more aggressive phenotype.