Our results demonstrate that in less-differentiated PCa cells, a decrease in the expression of SATB1 in the NM and a minor fragmentation are associated with higher colocalization with the XmnI sequence, thus supporting the model that SATB1 acts as a structural platform that provides a base for chromatin loops [36] and suggesting that, in PCa cell differentiation, the level of interaction of SATB1 with MAR sequences could be more important than its expression level. Here, SATB1 is linked to posterior cortical atrophy.