Furthermore, transcriptional down-regulation of androgen receptor in the aging rat liver and in oxidatively stressed hepatoma cells is regulated by PARP1 in association with hnRNP K [39], which is the NM protein that has a pivotal role in PCa and the one that we found to be highly expressed in less-differentiated tumors [9]. The gene discussed is GNE; the disease is hepatocellular carcinoma.