PRKD1 and cancer: Cell-matrix interactions and migration are the key properties of the metastatic cancer cells, and the first step in this process involves cytoskeletal remodeling, mainly controlled by small Rho GTPases [27].Two independent studies identified protein kinase D (PKD) as a candidate protein associated with F-actin formation and interacts with 14-3-3 in the regulation of cytoskeletal assembly [28], [29].