In this context animal models have shown that early life events in terms of stress, recognized as a major susceptibility factor for depression, can change the DNA methylation level of genes, being implicated in the neurobiology of depression, as glial cell-derived neurotrophic factor (GDNF), glutamic acid decarboxylase 1 (GAD1), estrogen receptor alpha 1b (ERA1B), arginine vasopressin (AVP), glucocrtiocoid receptor (NR3C1) and serotonin transporter (5-HTTP) [9]–[14]. This evidence concerns the gene GAD1 and major depressive disorder.