TP53 and cancer: Many of the other candidate genes identified by our analysis also have functions associated with the control of processes known to contribute to cancer cell proliferation and survival, including regulators of various signalling pathways including EGFR (EPS15R [54]), Ras (RASAL-1 [55]) and ERK (DUSP7 [56]), calcium transportation (ATP2B4 [57], [58]), p53 activation (UNC5B [59]) and hormone metabolism (CYP1B1 [60]).