Further elucidation of the differences in drug-induced outcomes for GNAQ and BRAF mutant uveal melanomas revealed that AKT, 4E-BP1, and MCL-1 were cooperatively regulated by the AZD8055/selumetinib combination only in BRAF mutant cells and not GNAQ cells (Figure 8A), suggesting these as candidate targets responsible for the distinct apoptotic outcomes observed. This evidence concerns the gene MCL1 and uveal melanoma.