EGFR and non-small cell lung carcinoma: In epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer cells, MCL-1 downregulation by a PI3K/mTOR kinase inhibitor in combination with BIM upregulation (a pro-apoptotic member of the bcl-2 family) by a MEK inhibitor has been shown to be critical for the induction of apoptosis [27].