ARID1A and ovarian cancer: Guan et al. demonstrated that restoring the expression of wild-type ARID1A is sufficient to suppress the proliferation and tumorigenecity of xenografts with human ovarian cancer cell lines harboring ARID1A mutations, while RNA interference-mediated ARID1A silencing enhances cellular proliferation and tumorigenicity in two non-transformed human ovarian epithelial cell lines, IOSE-80PC and OSE4 [27].