In addition, we discovered a substantial number of SHM targets in DLBCL cells, including novel targets, such as BACH2, BTG2, CIITA, CXCR4, EBF1, PIM2, and TCL1A, that have been shown to play important role in B-cell differentiation and proliferation, suggesting that AICDA-induced SHM is mis-targeted to these genes in DLBCL cells. Here, CIITA is linked to diffuse large B-cell lymphoma.