The effects of extracellularly delivered MDA-7/IL-24 are mediated through interactions with IL-20Rα/β receptors on the cell surface, and the natural secretion of MDA-7/IL-24 leads to “bystander” effects via binding to surface receptors on adjacent and distant tumor cells resulting in stabilization, production and secretion of MDA-7/IL-24 by autocrine/paracrine processes [25], [26]. The gene discussed is IL24; the disease is neoplasm.