Therefore, despite enormous progress, there is still a need to optimize IFN-α-based (or IFN-α-free) treatment regimens for chronic hepatitis C, and the establishment of algorithms (including, for example, on-treatment viral kinetics and IL28B genotype) to select appropriate treatment regimens for individual patients remains highly relevant [9]–[15]. This evidence concerns the gene IFNA17 and chronic hepatitis C virus infection.