TSR expressing B16F1 cells produced larger and more vascular tumors in cd36 null mice (Figures 6A, 7A left and 7B top) and smaller and less vascular tumors in hrgp null mice (Figures 6B, 7A right and 7B bottom) when compared to age and sex matched wildtype controls. The gene discussed is HRG; the disease is vascular neoplasm.