To determine whether Lin28 expression is associated with chemoresistance of tumor cells, we examined the expression of Lin28 by RT-PCR in the human lung cancer cell line H460 and its corresponding paclitaxel-resistant (H460/PacR) and vincristine-resistant (H460/VinR) subclones, and in the human colon cancer cell line DLD1 and its corresponding 5-Fu-resistant subclones (DLD1/5-FuR). This evidence concerns the gene LIN28A and lung cancer.