ABCB5 and melanoma: ABCB6 belongs to the B sub-family of ABC transporters, which includes the well-characterized human transporter ABCB1 that was the first ABC transporter implicated in multidrug resistance, the intracellular peptide transporters (TAP1 and TAP2) that function in major histocompatibility complex class I antigen presentation and ABCB5 which is essential for melanoma induction, as a doxorubicin efflux mediator in melanomas and xenotransplantation proliferation models [3], [5].