Finally, networks #4 and #5 (Table 2) reveal disease-related molecules associated with the dataset that include Rac1/RhoA (Figure S3, score 24, 13 genes) which is involved in valvular cell contractility and activation [35], and Notch1 and cyclin D (CCND1) (Figure S4, score 19, 11 genes) which are involved in proliferation processes and thus logical players in CAVD pathogenesis [36]. The gene discussed is NOTCH1; the disease is congenital bilateral aplasia of vas deferens from CFTR mutation.