TNF and neoplasm: Figure 6A shows that the serum TNF-α levels are gradually increased from the third weeks up to six weeks post tumor inoculation, however, no significant difference is found among tumor-bearing mice treated with and without mirtazapine, respectively. On the other hand, the TNF-α levels in tumors of mice (Always, Concurrent, and After) assayed with ex vivo Western blotting on day 42 post tumor inoculation were decreased to 40% of that of “Never” as shown in Figure 6B.