In addition, earlier mirtazapine intervention, such as always and concurrent, resulted in significantly higher IFN-γ expression as compared with that of after. Notably, Figures 5A and 5B show that significantly increased numbers of infiltrating CD4+ and CD8+ cells/0.1 mm2 tumor tissues of “concurrent” and “always” as compared with those of “never”, and were quantified in Figure 5C, p<0.01 and p<0.001, respectively. Here, CD4 is linked to neoplasm.