In a category of ubiquitinylation (Table S4), EPO induced the expression of Usp12 and Fbxw7. Usp12 is a deubiquitinating enzyme previously implicated in Fanconi anemia, while Fbxw7 (a substrate binding component of Ub ligase complexes) can act as a tumor suppressor in part by regulating Mcl1 levels [48]. Here, EPO is linked to neoplasm.