GRIK2 and familial pancreatic carcinoma: Inhibition of glutamate release and/or glutamate receptor activity can inhibit the proliferation and/or invasion of tumor cells in breast cancer [21], laryngeal cancer [22], and pancreatic cancer [23], and ionotrpic glutamate receptor (GLUR6) was also suggested to play a tumor-suppressor role in gastric cancer [24].