Here, Lyn inhibitors, such as Dasatinib, enhanced the effectiveness of ATRA through a positive feedback loop involving a scaffolding protein (KSR1) that complexes regulators of the MAP kinase pathway with Lyn, illustrating the potential for using Lyn/SFK inhibitors as adjunct therapies in combination with other anti-AML effectors [86]. This evidence concerns the gene LYN and acute myeloid leukemia.