AKT1 and B-cell chronic lymphocytic leukemia: Interestingly, in B-CLL cells overexpressing the phosphatase PTPN22, their acquired inhibition of antigen-induced apoptosis and positive regulation of an anti-apoptotic Akt pathway, is due to a selective uncoupling of the Akt pathway that Lyn regulates down-stream of the B-cell receptor [97].