Speculatively, these findings indicate that loss of RBM3 may be associated with a switch towards a more invasive and/or metastatic rather than proliferative phenotype, while up-regulated MCM3 expression may either be associated with increased proliferation or functions beyond DNA licensing, i.e. cell migration and invasion, as demonstrated in medulloblastoma cells [20]. This evidence concerns the gene MCM3 and medulloblastoma.