Head & neck and colon cancers have significantly high incidence of PHD2 (86% in head & neck, and 83% in colon) and PHD3 (21% in head & neck, and 50% in colon), and low incidence of HIF-α (38% in head & neck, and 27% in colon) (Figure 1C) compared to ccRCC. This evidence concerns the gene EGLN3 and nonpapillary renal cell carcinoma.