Among all kidney cancers, clear cell renal cell carcinoma (ccRCC) is the most common with a molecularly distinct phenotype [3] and contain up to 91% nonfunctional VHL mutations [1] which may leads to the constitutive expression of hypoxia inducible factors 1 and 2 alpha (HIF-α). Here, VHL is linked to nonpapillary renal cell carcinoma.