LRRK2 and Parkinson disease: For example, increased FoxO3a has been found localized to Lewy bodies and Lewy neurites in Parkinson’s disease brain tissue (Su et al. 2009) and activation of FoxO by LRRK2, associated with autosomal-dominant late-onset Parkinson’s disease, enhances neuronal cell death in Drosophila (Kanao et al. 2010).