NR3C1 and obesity due to melanocortin 4 receptor deficiency: Obesity in CS is characterized by increased food intake with no changes in energy expenditure, reduced lean mass, and increased body weight with a redistribution of fat mass from peripheral toward central sites of the body, mainly in the truncal region and visceral depots.44 This is not surprising if one considers that glucocorticoids (GCs) promote both the differentiation and the proliferation of human adipocytes through glucocorticoid receptors (GRs), which are more abundantly expressed in visceral than in subcutaneous adipose tissue.45