In the pathogenesis of GC-induced obesity, the relevance of individual sensitivity to GC exposure has been proposed and supported by genetic studies on the GR.56 The GR is a ubiquitously expressed protein, encoded by exons 2–9 of the GR gene, located on chromosome 5 (5q31–32).57,58 Alternative splicing of the GR precursor mRNA gives rise to 5 GR protein subtypes, termed GRα, GRβ, GRγ, GR-A, and GR-P. The gene discussed is NR3C1; the disease is obesity due to melanocortin 4 receptor deficiency.