Certainstudies have suggested that IFN-γsecretion enhances IL-10 production,particularly in disease conditions in which the host has already been primedto antigen, such as in chronic infection or cancer [49].Antigen-experienced T cells appear to require IFN-γ to further enhanceIL-10 secretion for the inhibition of antigen-specific T cell responses [49]. The gene discussed is IL10; the disease is cancer.