IFNG and viral infectious disease: Previousstudies report that CD25+ cell depletion results in a significantincrease in IFN-γ production in splenocyte culture supernatants, decreasesthe production of IL-10 in viral infection, and enhances the specific immuneresponse induce by viral infection [33].In contrast, this study found that CD25+ cell depletion causesan increase in both pro-inflammatory cytokines (e.g. IFN-γ, GM-CSF andIL-4) and an anti-inflammatory cytokine (e.g. IL-10).