Furthermore, these results appear inconsistentwith previous studies, as a number of groups have shown that removal of CD4+CD25+Tregs with anti-CD25 treatment enhances both the immune response and therapeuticpotency of vaccines [16], [17], [23], [36], [37].However, consistent with the current work, Tuve and colleagues report thatCD4+CD25+ Tregs depletion is inefficient incontrolling tumor growth in a mouse model of cervical cancer [38]. This evidence concerns the gene CD4 and cervical cancer.