Work by our group has demonstrated that Ac-SDKP can inhibit pulmonary fibrosis in rats with SiO2-induced silicosis by inhibiting chronic inflammation, TGF-β1/Smad signal, and TGF-β1 induced pulmonary fibroblast proliferation and collagen synthesis [6], [25], [26]. This evidence concerns the gene TGFB1 and silicosis.