COMT and 22q11.2 deletion syndrome: Hsa-miR-185* was first identified in a human neuroblastoma cell line treated with retinoic acid [44] and its locus maps to the velocardiofacial syndrome region on 22q11.2, which has been of significant interest to psychiatry because it is the region deleted in Velocardiofacial/DiGeorge’s syndrome, where ARVCF, COMT and DGCR8 genes are located.