ATP7B and Nephropathy: Thetime-dependent kidney damage could be either due to increased amounts of copperbeing filtered through kidney or, more likely, due to inactivation of renalAtp7b and copper misbalance in kidney cells.Atp7b is normally expressed in kidneys at relatively highlevels [17]–[19] and inactivation of Atp7b is likely toalter normal copper homeostasis.