Subsequently, the study of MFS mouse models suggested an important role for the cytokine transforming growth factor beta (TGFβ) in the pathogenesis of MFS; Fbn1 deficient mice showed increased TGFβ activation and signaling and TGFβ antagonism rescued various MFS phenotypes [19, 36, 37]. Here, TGFB1 is linked to Marfan syndrome.