MYD88 and ischemia: Recently, we found no significant differences in infarct size or neuron survival in models of focal, global or in vitro ischemia in mice with deletions or mutations of the downstream TLR signaling adaptor molecules Myeloid-dependent protein-88 (MyD88) and Toll/interleukin 1 receptor domain-containing adaptor-inducing interferon β (TRIF).